[Combination therapy of antibiotics and intravenous immunoglobulin]

Abstract

A large scale multicenter randomized controlled study was conducted to evaluate the efficacy of intravenous immunoglobulin in combination with IPM/CS and AMK in 504 evaluable patients who did not respond by 3 day therapy with beta-lactum and aminoglucoside. Immunoglobulin 5 g was administered 3 days to the patients allocated to immunoglobulin group. A completely automatic computer evaluation was performed according to the criteria determined by the committee. The response rate was 61.5% in immunoglobulin group and 47.3% in control group(p < 0.001). Intravenous immunoglobulin is considered effective for severe infection when used as combination therapy with antibiotics.