Pharmacologic inhibitors of MKK1 and MKK2

Methods Enzymol. 2001;332:417-31. doi: 10.1016/s0076-6879(01)32219-x.
No abstract available

MeSH terms

  • 3T3 Cells
  • Animals
  • Antibody Specificity
  • Benzimidazoles / chemistry
  • Benzimidazoles / pharmacology
  • Butadienes / chemistry
  • Butadienes / pharmacology
  • Cell Differentiation / drug effects
  • Drug Evaluation, Preclinical
  • Drug Stability
  • Enzyme Activation
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology
  • Humans
  • In Vitro Techniques
  • K562 Cells
  • MAP Kinase Kinase 1
  • MAP Kinase Kinase 2
  • MAP Kinase Kinase Kinase 1*
  • Megakaryocytes / cytology
  • Megakaryocytes / drug effects
  • Mice
  • Mitogen-Activated Protein Kinase Kinases / antagonists & inhibitors*
  • Mitogen-Activated Protein Kinase Kinases / genetics
  • Mitogen-Activated Protein Kinase Kinases / metabolism
  • Mutation
  • Nitriles / chemistry
  • Nitriles / pharmacology
  • Phosphorylation
  • Protein-Serine-Threonine Kinases / antagonists & inhibitors*
  • Protein-Serine-Threonine Kinases / genetics
  • Protein-Serine-Threonine Kinases / metabolism
  • Protein-Tyrosine Kinases / antagonists & inhibitors*
  • Protein-Tyrosine Kinases / genetics
  • Protein-Tyrosine Kinases / metabolism
  • Rats
  • Recombinant Proteins / antagonists & inhibitors
  • Recombinant Proteins / genetics
  • Recombinant Proteins / metabolism
  • Transfection

Substances

  • Benzimidazoles
  • Butadienes
  • Enzyme Inhibitors
  • Nitriles
  • PD 58491
  • Recombinant Proteins
  • U 0126
  • MAP2K2 protein, human
  • Protein-Tyrosine Kinases
  • Protein-Serine-Threonine Kinases
  • MAP Kinase Kinase Kinase 1
  • MAP3K1 protein, human
  • Map3k1 protein, mouse
  • MAP Kinase Kinase 1
  • MAP Kinase Kinase 2
  • MAP2K1 protein, human
  • Map2k1 protein, mouse
  • Mitogen-Activated Protein Kinase Kinases