Abstract
The methanolic extract of Apium graveolens seeds was investigated for bioactive compounds and resulted in the isolation and characterization of mosquitocidal, nematicidal, and antifungal compounds sedanolide (1), senkyunolide-N (2), and senkyunolide-J (3). Their structures were determined by 1H and 13C NMR spectral methods. Compounds 1-3 gave 100% mortality at 25, 100, and 100 microg mL(-1), respectively, on the nematode, Panagrellus redivivus. Compound 1 showed 100% mortality at 50 microg mL(-1) on nematode, Caenorhabditis elegans, and fourth-instar mosquito larvae, Aedes aegyptii. Also, it inhibited the growth of Candida albicans and Candida parapsilasis at 100 microg mL(-1). Compounds 2 and 3 were isolated for the first time from A. graveolens. This is the first report of the mosquitocidal, nematicidal, and antifungal activities of compounds 1-3.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Aedes / drug effects
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Animals
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Antifungal Agents / chemistry
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Antifungal Agents / isolation & purification*
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Antifungal Agents / pharmacology
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Antinematodal Agents / chemistry
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Antinematodal Agents / isolation & purification*
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Antinematodal Agents / pharmacology
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Apiaceae*
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Benzofurans / chemistry
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Benzofurans / isolation & purification
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Benzofurans / pharmacology
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Caenorhabditis elegans / drug effects
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Candida / drug effects
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Candida / growth & development
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Insecticides / chemistry
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Insecticides / isolation & purification*
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Insecticides / pharmacology
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Methanol
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Nematoda / drug effects
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Plant Extracts / chemistry
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Seeds / chemistry*
Substances
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Antifungal Agents
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Antinematodal Agents
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Benzofurans
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Insecticides
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Plant Extracts
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3-N-butyl-4,5-dihydrophthalide
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Methanol