The TRAP/SMCC/Mediator complex and thyroid hormone receptor function

Trends Endocrinol Metab. 2001 Apr;12(3):127-34. doi: 10.1016/s1043-2760(00)00355-6.

Abstract

The TRAP/SMCC/Mediator complex is a mammalian transcriptional regulatory complex that contains over 25 polypeptides and is, in part, phylogenetically conserved. It was originally isolated as a thyroid hormone receptor (TR)-associated protein (TRAP) complex that mediates TR-activated transcription from DNA templates in conjunction with the general transcription machinery, and probably acts in vivo after the action of other receptor-interacting coactivators involved in chromatin remodeling. Subsequently, the TRAP complex was identified as a more broadly used coactivator complex for a wide variety of activators. The TRAP220 subunit mediates ligand-dependent interactions of the complex with TR and other nuclear receptors; and genetic ablation of murine TRAP220 has revealed that it is essential both for optimal TR function and for a variety of early developmental and adult homeostasis events in mice, but not for cell viability per se.

Publication types

  • Review

MeSH terms

  • Animals
  • Caenorhabditis elegans / genetics
  • Carrier Proteins / genetics*
  • Carrier Proteins / metabolism*
  • Drosophila Proteins*
  • Drosophila melanogaster / genetics
  • Embryo, Mammalian
  • Embryo, Nonmammalian
  • Fungal Proteins / metabolism*
  • Hypothyroidism / genetics
  • Mediator Complex
  • Mediator Complex Subunit 1
  • Mice
  • Mutation
  • Receptors, Thyroid Hormone / physiology*
  • Saccharomyces cerevisiae Proteins*
  • Trans-Activators*
  • Transcription Factors / metabolism*

Substances

  • Carrier Proteins
  • Drosophila Proteins
  • Fungal Proteins
  • Med1 protein, mouse
  • Med6 protein, Drosophila
  • Mediator Complex
  • Mediator Complex Subunit 1
  • Receptors, Thyroid Hormone
  • SRB2 protein, S cerevisiae
  • Saccharomyces cerevisiae Proteins
  • Trans-Activators
  • Transcription Factors