The human Y chromosome derives largely from a single autosomal region added to the sex chromosomes 80-130 million years ago

Cytogenet Cell Genet. 2001;92(1-2):74-9. doi: 10.1159/000056872.


Mapping of human X-borne genes in distantly related mammals has defined a conserved region shared by the X chromosome in all three extant mammalian groups, plus a region that was recently added to the eutherian X but is still autosomal in marsupials and monotremes. Using comparative mapping of human Y-borne genes, we now directly show that the eutherian Y is also composed of a conserved and an added region which contains most of the ubiquitously expressed Y-borne genes. Little of the ancient conserved region remains, and the human Y chromosome is largely derived from the added region.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Blotting, Southern
  • Conserved Sequence / genetics*
  • Evolution, Molecular*
  • Female
  • Genes
  • Humans
  • In Situ Hybridization, Fluorescence
  • Male
  • Marsupialia / genetics*
  • Mice
  • Time Factors
  • X Chromosome / genetics
  • Y Chromosome / genetics*