Homing receptor expression on cord blood T lymphocytes and the development of atopic eczema in infants

Int Arch Allergy Immunol. 2001 Jan-Mar;124(1-3):332-5. doi: 10.1159/000053749.

Abstract

Expression of the gut-homing receptor integrin alphaEbeta7, but not cutaneous lymphocyte-associated antigen (CLA), on milk allergen-stimulated cord blood T lymphocytes precedes the development of milk-induced eczema in early infancy. The data indicate the involvement of integrin alphaEbeta7 in the development of infantile allergic eczema and provide a clue to the avoidance of specific allergens and novel therapy targeting homing receptors in food allergy.

MeSH terms

  • Allergens / immunology
  • Antigens, Differentiation, T-Lymphocyte
  • Antigens, Neoplasm
  • Caseins / immunology
  • Cells, Cultured
  • Dermatitis, Atopic / immunology*
  • Fetal Blood / immunology*
  • Humans
  • Infant
  • Integrins / biosynthesis*
  • Lymphocyte Activation
  • Membrane Glycoproteins / biosynthesis
  • Milk Hypersensitivity / immunology*
  • Receptors, Lymphocyte Homing / biosynthesis*
  • T-Lymphocytes / immunology*

Substances

  • Allergens
  • Antigens, Differentiation, T-Lymphocyte
  • Antigens, Neoplasm
  • CTAGE1 protein, human
  • Caseins
  • Integrins
  • Membrane Glycoproteins
  • Receptors, Lymphocyte Homing
  • integrin alphaEbeta7