Depressor and regionally-selective vasodilator effects of human and rat urotensin II in conscious rats

Br J Pharmacol. 2001 Apr;132(8):1625-9. doi: 10.1038/sj.bjp.0704051.


The regional haemodynamic effects of rat or human urotensin II (U-II) 3, 30, 300 and 3000 pmol kg(-1), i.v.) were assessed in separate groups of conscious, unrestrained, male, Sprague-Dawley rats (n=8 in each). Rat and human U-II had similar effects. At a dose of 3 pmol kg(-1), neither peptide had any significant action, while at a dose of 30 pmol kg(-1), there was a transient mesenteric vasodilatation (significant only for rat U-II). At doses of 300 and 3000 pmol kg(-1), there were dose-dependent tachycardias, and mesenteric and hindquarters hyperaemic vasodilatations. Thus, in conscious rats, the predominant cardiovascular action of rat and human U-II is vasodilatation. This is in contrast to recent findings with human U-II in non-human primates, but is consistent with effects on human isolated resistance vessels.

MeSH terms

  • Animals
  • Blood Pressure / drug effects
  • Depression, Chemical
  • Dose-Response Relationship, Drug
  • Heart Rate / drug effects
  • Hemodynamics / drug effects*
  • Humans
  • Male
  • Oligopeptides / chemistry
  • Oligopeptides / pharmacology
  • Rats
  • Rats, Sprague-Dawley
  • Splanchnic Circulation / drug effects
  • Urotensins / pharmacology*
  • Vasodilator Agents / pharmacology*


  • Oligopeptides
  • Urotensins
  • Vasodilator Agents
  • urotensin II