Cellular immune responses to HIV

Nature. 2001 Apr 19;410(6831):980-7. doi: 10.1038/35073658.

Abstract

The cellular immune response to the human immunodeficiency virus, mediated by T lymphocytes, seems strong but fails to control the infection completely. In most virus infections, T cells either eliminate the virus or suppress it indefinitely as a harmless, persisting infection. But the human immunodeficiency virus undermines this control by infecting key immune cells, thereby impairing the response of both the infected CD4+ T cells and the uninfected CD8+ T cells. The failure of the latter to function efficiently facilitates the escape of virus from immune control and the collapse of the whole immune system.

Publication types

  • Review

MeSH terms

  • AIDS Vaccines
  • Animals
  • CD4-Positive T-Lymphocytes / immunology*
  • CD4-Positive T-Lymphocytes / virology
  • CD8-Positive T-Lymphocytes / immunology*
  • Cytotoxicity, Immunologic
  • HIV / immunology*
  • HIV Infections / immunology*
  • Humans
  • Immune Tolerance
  • Lymphocyte Activation
  • T-Lymphocytes, Cytotoxic / immunology
  • T-Lymphocytes, Helper-Inducer / immunology

Substances

  • AIDS Vaccines