Synthesis of 2-substituted trifluoromethylquinolines for the evaluation of leishmanicidal activity

J Dade; O Provot; H Moskowitz; J Mayrargue; E Prina

doi:10.1248/cpb.49.480

Synthesis of 2-substituted trifluoromethylquinolines for the evaluation of leishmanicidal activity

Chem Pharm Bull (Tokyo). 2001 Apr;49(4):480-3. doi: 10.1248/cpb.49.480.

Authors

J Dade¹, O Provot, H Moskowitz, J Mayrargue, E Prina

Affiliation

¹ Laboratoire de Chimie organique, Faculté de Pharmacie, UPRES-A CNRS 8076, Université de Paris-Sud, Clément, Châtenay-Malabry, France.

PMID: 11310679
DOI: 10.1248/cpb.49.480

Abstract

The synthesis of 2-substituted-trifluoromethylquinolines from aniline, trifluoromethylanilines, 3-aminoquinoline and trifluoromethylquinaldines is reported. In vitro antileishmanial evaluation of 2-alkyl, 2-alkenyl and 2-epoxypropyl-trifluoromethylquinolines is presented.

MeSH terms

Animals
Antiprotozoal Agents / chemical synthesis*
Antiprotozoal Agents / pharmacology*
Chromatography, Thin Layer
Indicators and Reagents
Leishmania / drug effects*
Leishmania donovani / drug effects
Leishmania infantum / drug effects
Leishmania mexicana / drug effects
Magnetic Resonance Spectroscopy
Quinolines / chemical synthesis*
Quinolines / pharmacology*

Substances

Antiprotozoal Agents
Indicators and Reagents
Quinolines