Subjective effects of MDMA ('Ecstasy') on human sexual function

Eur Psychiatry. 2001 Mar;16(2):127-30. doi: 10.1016/s0924-9338(01)00550-8.


Sexual function following 3,4-Methylenedioxymethamphetamine (MDMA, or 'Ecstasy') consumption was subjectively evaluated in 35 healthy recreational users (20 men and 15 women, aged 21-48 years) with regard to four major domains of sexual activity: desire, erection (lubrication in women), orgasm and satisfaction. Desire and satisfaction were moderately to profoundly increased by MDMA in more than 90% of subjects. Orgasm was delayed but perceived as more intense. Erection was impaired in 40% of the men. It seems that MDMA impairs sexual performance, in spite of enhancement of sexual desire and the perception of greater satisfaction.

MeSH terms

  • Adult
  • Female
  • Hallucinogens / adverse effects*
  • Humans
  • Libido / drug effects
  • Male
  • Middle Aged
  • N-Methyl-3,4-methylenedioxyamphetamine / adverse effects*
  • Sexual Dysfunction, Physiological / chemically induced*
  • Sexual Dysfunctions, Psychological / chemically induced


  • Hallucinogens
  • N-Methyl-3,4-methylenedioxyamphetamine