Corneal topography changes after a 15 second pause in blinking

J Cataract Refract Surg. 2001 Apr;27(4):589-92. doi: 10.1016/s0886-3350(01)00768-4.


Purpose: To examine the effect of a short pause in blinking on the quantitative topographic parameters of the corneal surface.

Setting: Refractive corneal surgery unit of a university eye hospital.

Methods: Using a TMS-1 instrument (Computed Anatomy, Inc.), corneal topographic parameters were measured 5 and 15 seconds after a complete blink in 12 healthy subjects. The main outcome measures were changes in the surface regularity index (SRI) and the surface asymmetry index (SAI).

Results: During the pause in blinking, the mean SRI value increased from 0.18 +/- 0.19 (SD) to 0.30 +/- 0.19 (P <.02) and the SAI from 0.21 +/- 0.08 to 0.24 +/- 0.10 (P =.079, not statistically significant). There were no significant changes in the values for potential visual acuity, corneal refractive power, or astigmatism.

Conclusion: The results indicated a significant change in corneal topography during even a short pause in blinking. In follow-up studies using corneal topography, all measurements should be done at a fixed time after a complete blink.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Blinking / physiology*
  • Cornea / anatomy & histology*
  • Corneal Topography*
  • Female
  • Humans
  • Male
  • Refraction, Ocular / physiology
  • Time Factors
  • Visual Acuity / physiology