Pleiotropic roles of formyl peptide receptors

Cytokine Growth Factor Rev. 2001 Mar;12(1):91-105. doi: 10.1016/s1359-6101(01)00003-x.


FPR and FPRL1 belong to the seven-transmembrane, G protein-coupled chemoattractant receptor superfamily. Because of their capacity to interact with bacterial chemotactic formylated peptides, these receptors are thought to play a role in host defense against microbial infection. Recently, a variety of novel agonists have been identified for these receptors, including several host-derived endogenous molecules that are involved in proinflammatory responses. Most notably is the use of FPRL1 by at least three amyloidogenic protein and peptide ligands, the serum amyloid A (SAA), the 42 amino acid form of beta amyloid (Abeta(42)), and the prion peptide PrP106-126, to chemoattract and activate human phagocytic leukocytes. These new findings have greatly expanded the functional scope of the formyl peptide receptors and call for more in-depth investigation of the role of these receptors in pathophysiological conditions.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amyloidosis / immunology*
  • Amyloidosis / physiopathology
  • Animals
  • Annexin A1 / metabolism
  • HIV Infections / immunology*
  • HIV Infections / physiopathology
  • Humans
  • Ligands
  • Neurodegenerative Diseases / immunology*
  • Neurodegenerative Diseases / physiopathology
  • Phosphorylation
  • Receptors, Formyl Peptide
  • Receptors, Immunologic / agonists
  • Receptors, Immunologic / antagonists & inhibitors
  • Receptors, Immunologic / physiology*
  • Receptors, Lipoxin*
  • Receptors, Peptide / agonists
  • Receptors, Peptide / antagonists & inhibitors
  • Receptors, Peptide / physiology*
  • Signal Transduction*


  • Annexin A1
  • FPR2 protein, human
  • Ligands
  • Receptors, Formyl Peptide
  • Receptors, Immunologic
  • Receptors, Lipoxin
  • Receptors, Peptide