The purpose is to examine the relationship between musculoskeletal fitness and health status. Muscular strength is positively associated with independence and overall quality of life, and negatively associated with morbidity and potentially premature mortality. Muscular endurance is positively related to overall quality of life. Elevated muscular endurance may reduce the incidence of falling and its associated injuries. Muscular power is predictive of functional capacity, resultant disability, and potentially premature mortality. Flexibility is positively associated with mobility and independence. Women and the aged may be susceptible to musculoskeletal impairments leading to reduced health status and thus may represent primary target groups for intervention programs. High levels of musculoskeletal fitness are associated with positive health status, and low levels of musculoskeletal fitness are associated with lower health status.