Skin and nail changes in children with sickle cell anemia receiving hydroxyurea therapy

J Am Acad Dermatol. 2001 May;44(5):859-61. doi: 10.1067/mjd.2001.113471.


Skin and nail changes from long-term hydroxyurea therapy are reported in adults. Skin and nail changes, including nail hyperpigmentation, longitudinal bands, and hyperpigmentation of the palms and other skin surfaces, developed in 7 children with sickle cell anemia after 6 to 16 weeks of hydroxyurea therapy. Cutaneous and nail changes may occur in children receiving hydroxyurea.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Anemia, Sickle Cell / drug therapy*
  • Antisickling Agents / adverse effects*
  • Child
  • Female
  • Humans
  • Hydroxyurea / adverse effects*
  • Hyperpigmentation / etiology*
  • Hyperpigmentation / pathology
  • Male
  • Nail Diseases / etiology*
  • Nail Diseases / pathology
  • Skin Diseases / etiology*


  • Antisickling Agents
  • Hydroxyurea