Ursodeoxycholic acid does not interfere with in vivo Helicobacter pylori colonization

Rev Hosp Clin Fac Med Sao Paulo. 2000 Nov-Dec;55(6):201-6. doi: 10.1590/s0041-87812000000600002.


A low frequency of Helicobacter pylori in the gastric mucosa of patients with alkaline gastritis has been reported. At the same time, it can be noted that the growth of bacteria can be inhibited by bile acids. We studied 40 patients with chronic gastritis related to Helicobacter pylori in order to determine the effect of ursodeoxycholic acid on this infection. Diagnoses of the infection and the inflammatory process were obtained by histologic study of gastric biopsies collected during endoscopy. Two groups were studied: group I received ursodeoxycholic acid - 300 mg/day, and group II received the placebo, twice a day, both for 28 days. The colonization by Helicobacter pylori and the intensity of the mononuclear and polymorphonuclear inflammatory infiltrate were determined before (time 1) and after (time 2) treatment. Ursodeoxycholic acid had no effect on the Helicobacter pylori infection. A significant reduction in the intensity of the mononuclear inflammatory infiltrate of the gastric antrum mucosa was observed in patients from group I, when we compared not only times 1 and 2 but also groups I and II. However, this was not the case with the body mucosa. We concluded that ursodeoxycholic acid had no action on the colonization by Helicobacter pylori or on the polymorphonuclear inflammatory infiltrate, but it caused a significant reduction in the intensity of the mononuclear inflammatory infiltrate of the gastric antrum.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Cholagogues and Choleretics / pharmacology*
  • Cholagogues and Choleretics / therapeutic use
  • Female
  • Gastric Mucosa / drug effects
  • Gastric Mucosa / microbiology*
  • Gastritis / drug therapy
  • Gastritis / microbiology*
  • Helicobacter pylori / drug effects*
  • Helicobacter pylori / growth & development
  • Humans
  • Male
  • Pyloric Antrum / drug effects
  • Pyloric Antrum / microbiology
  • Ursodeoxycholic Acid / pharmacology*
  • Ursodeoxycholic Acid / therapeutic use


  • Cholagogues and Choleretics
  • Ursodeoxycholic Acid