Experimental study of phosphopeptide in promoting tooth remineralization

Chin J Dent Res. 2000 May;3(1):27-30.

Abstract

Objective: To explore a new method for effective and safe prevention and treatment of caries.

Methods: Following the theory of tooth remineralization, we searched for the mechanism and clinical application of tooth remineralization with phosphopeptide.

Results: Phosphopeptide, with calcium and phosphorus, had a high affinity for hydroxyapatite and could enhance tooth remineralization.

Conclusion: Phosphopeptide was effective in the prevention and treatment of tooth decay. Clinically, it could be safely applied.

MeSH terms

  • Animals
  • Calcium Phosphates / chemistry
  • Calcium Phosphates / therapeutic use
  • Cariostatic Agents / therapeutic use*
  • Chemical Precipitation
  • Dental Caries / prevention & control
  • Dental Enamel / drug effects
  • Dental Enamel / ultrastructure
  • Diet, Cariogenic
  • Durapatite / chemistry
  • Female
  • Hardness
  • Humans
  • Microscopy, Polarization
  • Phosphates / chemistry
  • Phosphoproteins / chemistry
  • Phosphoproteins / therapeutic use*
  • Potassium Compounds / chemistry
  • Rats
  • Rats, Sprague-Dawley
  • Solubility
  • Tooth Demineralization / prevention & control
  • Tooth Remineralization*
  • Toothpastes / therapeutic use

Substances

  • Calcium Phosphates
  • Cariostatic Agents
  • Phosphates
  • Phosphoproteins
  • Potassium Compounds
  • Toothpastes
  • alpha-tricalcium phosphate
  • tetracalcium phosphate
  • calcium phosphate, monobasic, anhydrous
  • Durapatite
  • calcium phosphate
  • potassium phosphate
  • calcium phosphate, dibasic, anhydrous