A new model for the origins of chronic disease

Med Health Care Philos. 2001;4(1):31-5. doi: 10.1023/a:1009934412988.


Living things are often plastic during their early development and are moulded by the environment. Many human fetuses have to adapt to a limited supply of nutrients, and in doing so they permanently change their physiology and metabolism. These programmed changes may be the origins of a number of diseases in later life, including coronary heart disease, stroke, diabetes and hypertension.

Publication types

  • Review

MeSH terms

  • Causality
  • Chronic Disease*
  • Coronary Disease / etiology
  • Embryonic and Fetal Development / physiology*
  • Female
  • Genetics, Medical
  • Humans
  • Life Expectancy
  • Male
  • Models, Biological*
  • Nutritional Physiological Phenomena / physiology*
  • Placental Insufficiency / complications*
  • Pregnancy