A global goodness-of-fit statistic for Cox regression models

Biometrics. 1999 Jun;55(2):580-4. doi: 10.1111/j.0006-341x.1999.00580.x.


In this paper, a global goodness-of-fit test statistic for a Cox regression model, which has an approximate chi-squared distribution when the model has been correctly specified, is proposed. Our goodness-of-fit statistic is global and has power to detect if interactions or higher order powers of covariates in the model are needed. The proposed statistic is similar to the Hosmer and Lemeshow (1980, Communications in Statistics A10, 1043-1069) goodness-of-fit statistic for binary data as well as Schoenfeld's (1980, Biometrika 67, 145-153) statistic for the Cox model. The methods are illustrated using data from a Mayo Clinic trial in primary billiary cirrhosis of the liver (Fleming and Harrington, 1991, Counting Processes and Survival Analysis), in which the outcome is the time until liver transplantation or death. The are 17 possible covariates. Two Cox proportional hazards models are fit to the data, and the proposed goodness-of-fit statistic is applied to the fitted models.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Biometry*
  • Chi-Square Distribution
  • Humans
  • Likelihood Functions
  • Liver Cirrhosis, Biliary / mortality
  • Liver Cirrhosis, Biliary / surgery
  • Liver Transplantation
  • Proportional Hazards Models*
  • Regression Analysis
  • Survival Analysis