Prevention of axial elongation in myopia by the trace element zinc

Biol Trace Elem Res. 2001 Jan;79(1):39-47. doi: 10.1385/BTER:79:1:39.


The effect of the trace element zinc on the change in the axial length and diopters and the variations of activities of superoxide dismutase (SOD) and nitric oxide synthase (NOS), and the content of NO in the retino pigmental epithelium choroid homogenate of the myopic eyes in form-sense-deprived chicks were studied. The results show that zinc can inhibit the elongation of axis oculi and increase the diopters in myopia. Meanwhile, the activities of SOD and NOS and the content of NO are significantly increased compared with the model group, indicating that zinc can be used to prevent and treat myopia to a certain extent.

MeSH terms

  • Animals
  • Chickens
  • Disease Models, Animal
  • Myopia / drug therapy
  • Myopia / metabolism*
  • Nitric Oxide Synthase / metabolism
  • Pigment Epithelium of Eye / enzymology
  • Pigment Epithelium of Eye / metabolism
  • Superoxide Dismutase / metabolism
  • Trace Elements / metabolism*
  • Zinc / metabolism*
  • Zinc / therapeutic use


  • Trace Elements
  • Nitric Oxide Synthase
  • Superoxide Dismutase
  • Zinc