A retrotransposon-derived gene, PEG10, is a novel imprinted gene located on human chromosome 7q21

Genomics. 2001 Apr 15;73(2):232-7. doi: 10.1006/geno.2001.6494.

Abstract

A novel paternally expressed imprinted gene, PEG10 (Paternally Expressed 10), was identified on human chromosome 7q21. PEG10 is located near the SGCE (Sarcoglycan epsilon) gene, whose mouse homologue was recently shown to be imprinted. Therefore, it is highly possible that a new imprinted gene cluster exists on human chromosome 7q21. Analysis of two predicted open reading frames (ORF1 and ORF2) revealed that ORF1 and ORF2 have homology to the gag and pol proteins of some vertebrate retrotransposons, respectively. These data suggest that PEG10 is derived from a retrotransposon that was previously integrated into the mammalian genome. PEG10 is likely to be essential for understanding how exogenous genes become imprinted.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Choriocarcinoma / genetics
  • Chromosomes, Human, Pair 7*
  • Female
  • Genes, gag / genetics
  • Genes, pol / genetics
  • Genomic Imprinting*
  • Humans
  • Male
  • Mice
  • Molecular Sequence Data
  • Nuclear Proteins / genetics
  • Open Reading Frames
  • Physical Chromosome Mapping / methods
  • Polymorphism, Genetic
  • Proteins / genetics*
  • Radiation Hybrid Mapping / methods
  • Retroelements*
  • Sequence Homology, Amino Acid
  • Syndrome
  • Transcription Factors / genetics

Substances

  • Nuclear Proteins
  • PEG10 protein, human
  • Peg10 protein, mouse
  • Proteins
  • Retroelements
  • Transcription Factors

Associated data

  • GENBANK/AB049834