Sequence Polymorphisms in PFCRT Are Strongly Associated With Chloroquine Resistance in Plasmodium Falciparum

J Infect Dis. 2001 May 15;183(10):1543-5. doi: 10.1086/320206.

Publication types

  • Letter

MeSH terms

  • Animals
  • Antimalarials / pharmacology
  • Antimalarials / therapeutic use*
  • Chloroquine / pharmacology
  • Chloroquine / therapeutic use*
  • Drug Resistance
  • Genes, Protozoan
  • Humans
  • Malaria, Falciparum / drug therapy*
  • Malaria, Falciparum / parasitology
  • Membrane Proteins / genetics*
  • Membrane Transport Proteins
  • Parasitic Sensitivity Tests
  • Plasmodium falciparum / drug effects*
  • Plasmodium falciparum / genetics
  • Plasmodium falciparum / isolation & purification
  • Polymorphism, Genetic*
  • Protozoan Proteins

Substances

  • Antimalarials
  • Membrane Proteins
  • Membrane Transport Proteins
  • PfCRT protein, Plasmodium falciparum
  • Protozoan Proteins
  • Chloroquine