Regulation of the cytoskeleton by Rho-family GTPases: implications for tumour cell invasion

Semin Cancer Biol. 2001 Apr;11(2):167-73. doi: 10.1006/scbi.2000.0367.


Rho-like GTPases regulate both cell-cell and cell-matrix adhesions and can influence the motile and invasive properties of tumour cells in vitro. Increased Rac signalling can promote either cell-cell adhesion or motility depending on the cell type and composition of the extracellular matrix. Ultimately, the balance of Rac and Rho activities and intracellular localization appears to be critical in determining the cellular phenotype.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Adhesion
  • Cell Movement
  • Cytoskeleton / metabolism*
  • Humans
  • Neoplasm Invasiveness*
  • Neoplasms / metabolism*
  • Neoplasms / pathology
  • rho GTP-Binding Proteins / physiology*


  • rho GTP-Binding Proteins