Macrophages and T-cell apoptosis in HIV infection: a leading role for accessory cells?

Trends Immunol. 2001 May;22(5):256-60. doi: 10.1016/s1471-4906(01)01898-1.


Recent studies indicate that macrophages modulate T-cell apoptosis in HIV infection. Macrophages have been shown to trigger apoptosis of uninfected bystander T cells and to protect HIV-infected T cells from apoptosis. This article raises the possibility that macrophages, via modulation of T-cell apoptosis, play a crucial role in both immune suppression and the formation of viral reservoirs during HIV infection.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antigen-Presenting Cells / immunology*
  • Apoptosis*
  • HIV Infections / immunology*
  • HIV Infections / virology*
  • Immune Tolerance*
  • Macrophage Activation
  • Macrophages / immunology
  • Macrophages / virology*
  • T-Lymphocytes / immunology
  • T-Lymphocytes / virology*