Frequency and CT findings of recurrent disease after lung transplantation

Radiology. 2001 May;219(2):503-9. doi: 10.1148/radiology.219.2.r01ma12503.


Purpose: To determine the frequency and computed tomographic (CT) findings of recurrence of the primary disease after lung transplantation at six North American lung transplantation centers.

Materials and methods: Medical records of 1,394 lung transplant recipients were reviewed to identify patients with recurrent primary disease. Their CT scans and pathologic specimens were reviewed.

Results: The frequency of disease recurrence in the six transplantation centers was 1% (15 of 1,394 patients), including six previously reported cases. Sarcoidosis recurred in nine (35%) of 26 transplants and was the most common disease to recur. Three (33%) of nine patients with recurrent sarcoidosis had correlative findings at CT. When present, CT findings were usually different at recurrence compared with pretransplantation CT findings.

Conclusion: A relatively small percentage of patients are at risk for recurrence of primary disease following lung transplantation. Sarcoidosis is the most common disease to recur.

MeSH terms

  • Adult
  • Female
  • Humans
  • Lung / diagnostic imaging
  • Lung / pathology
  • Lung Diseases / diagnostic imaging*
  • Lung Diseases / pathology
  • Lung Diseases / surgery
  • Lung Transplantation*
  • Male
  • Middle Aged
  • Recurrence
  • Sarcoidosis, Pulmonary / diagnostic imaging
  • Sarcoidosis, Pulmonary / pathology
  • Sarcoidosis, Pulmonary / surgery
  • Tomography, X-Ray Computed*