[A patient with nodal tachycardia after general anesthesia during medication with a selective serotonin reuptake inhibitor]

Anasthesiol Intensivmed Notfallmed Schmerzther. 2001 Mar;36(3):184-7. doi: 10.1055/s-2001-11822.
[Article in German]


We report on a 62 year old female patient treated with paroxetine, a selective serotonin reuptake inhibitor, because of an anxiety neurosis undergoing a vaginal hysterectomy in general anesthesia. Apart from a dietary treated diabetes mellitus there were no other diseases. There were no complications during the operation. At the end of the anesthesia an A-V nodal tachycardia appeared which spontaneously changed to a sinus rhythm ten hours after the end of the operation. No clinical or laboratory findings indicated a cardiac ischemia and an additional Holter ECG-Recording showed no further cardiac arrhythmias. No other complications occurred afterwards and the patient was discharged after two weeks. This case report demonstrates clearly that despite a reduced rate of cardiovascular complications compared to other types of antidepressants selective serotonin reuptake inhibitors can lead to perioperative cardiac arrhythmias.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Anesthesia, General / adverse effects*
  • Electrocardiography
  • Female
  • Humans
  • Hysterectomy
  • Middle Aged
  • Paroxetine / adverse effects*
  • Selective Serotonin Reuptake Inhibitors / adverse effects*
  • Tachycardia / chemically induced*
  • Tachycardia / pathology


  • Serotonin Uptake Inhibitors
  • Paroxetine