[The Effect of Lycium Barbarum Polysaccharide on Vascular Tension in Two-Kidney, One Clip Model of Hypertension]

Sheng Li Xue Bao. 1998 Jun;50(3):309-14.
[Article in Chinese]

Abstract

In the present study, the effects of lycium barbarum polysaccharide (LBP) on endothelial function in the two-kidney, one clip model of hypertension were observed. The results showed that the increase of blood pressure in hypertension rats (HR) could be prevented significantly by treatment with 10% LBP. In isolated aortic rings of LBP-treated rats, the contraction of phenylephrine (PE) was reduced as compared with HR rats. Removal of the endothelium abolished the difference of PE-induced vasoconstriction among groups. In vitro incubation of aortic rings from LBP-treated rats with methyl blue (MB) or N-nitro-L-arginine methyl ester (L-NAME) increased the magnitude of PE-induced contraction. Meanwhile the response to acetylcholine (ACh) was significantly increased in LBP-treated rats, but the response to nitroprusside had no significant difference among groups. Pretreatment with L-arginine partially restored ACh-induced relaxation in RH rats, but no effect in LBP-treated rats. These results suggested that the role of LBP in decreasing vasoconstriction to PE may be mediated by increase of the effects or/and production of endothelium-derived relaxation factor (EDRF). LBP increased formation of EDRF may be related to increase the substrate of EDRF.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Aorta / metabolism
  • Drugs, Chinese Herbal / chemistry
  • Drugs, Chinese Herbal / pharmacology*
  • Hypertension, Renovascular / metabolism*
  • In Vitro Techniques
  • Male
  • Nitric Oxide / metabolism*
  • Phenylephrine
  • Polysaccharides / isolation & purification
  • Polysaccharides / pharmacology*
  • Random Allocation
  • Rats
  • Rats, Wistar
  • Solanaceae / chemistry
  • Vasoconstriction / drug effects

Substances

  • Drugs, Chinese Herbal
  • Polysaccharides
  • Phenylephrine
  • Nitric Oxide