Microxine, a new cdc2 kinase inhibitor from the Australian marine sponge Microxina species

K B Killday; D Yarwood; M A Sills; P T Murphy; J N Hooper; A E Wright

doi:10.1021/np000546z

Microxine, a new cdc2 kinase inhibitor from the Australian marine sponge Microxina species

J Nat Prod. 2001 Apr;64(4):525-6. doi: 10.1021/np000546z.

Authors

K B Killday¹, D Yarwood, M A Sills, P T Murphy, J N Hooper, A E Wright

Affiliation

¹ Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, Inc., 5600 US 1 North, Ft. Pierce, Florida 34946, USA.

PMID: 11325241
DOI: 10.1021/np000546z

Abstract

A new purine derivative microxine (1) was isolated from the Australian marine sponge Microxina sp. The compound was isolated via reversed-phase chromatography and its structure determined spectroscopically. Microxine was found to weakly inhibit cdc2 kinase activity with an IC(50) of 13 microM.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
CDC2 Protein Kinase / antagonists & inhibitors*
Enzyme Inhibitors / chemistry
Enzyme Inhibitors / isolation & purification*
Enzyme Inhibitors / pharmacology
Molecular Structure
Porifera / chemistry*
Purines / chemistry
Purines / isolation & purification*
Purines / pharmacology
Spectrum Analysis

Substances

Enzyme Inhibitors
Purines
microxine
CDC2 Protein Kinase