Antibacterial diterpenes from the roots of Salvia blepharochlaena

J Nat Prod. 2001 Apr;64(4):549-51. doi: 10.1021/np0004956.

Abstract

The roots of Salvia blepharochlaena have yielded two new diterpenoids, blephaein (1) and O-methylpisiferic acid methyl ester (2), together with eight known diterpenoids. The structures of the new compounds were established by spectroscopic analysis and by some chemical reactions. Potent antibacterial activity was exhibited by the known compounds horminone (9) and 7-acetylhorminone (10) against Staphylococcus aureus ATCC 6538 P, Staphylococcus epidermidis ATCC 12226, and Bacillus subtilis ATCC 6633. Horminone was also found to be active against Enterococcus faecalis ATCC 29212.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / isolation & purification*
  • Anti-Bacterial Agents / pharmacology
  • Bacillus subtilis / drug effects
  • Diterpenes / chemistry
  • Diterpenes / isolation & purification*
  • Diterpenes / pharmacology
  • Enterococcus faecalis / drug effects
  • Lamiaceae / chemistry*
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Plant Roots / chemistry
  • Spectrum Analysis
  • Staphylococcus aureus / drug effects
  • Staphylococcus epidermidis / drug effects

Substances

  • Anti-Bacterial Agents
  • Diterpenes
  • O-methylpisiferic acid methyl ester
  • blephaein