Functional activities of the human T-cell leukemia virus type I Tax oncoprotein: cellular signaling through NF-kappa B

Cytokine Growth Factor Rev. Jun-Sep 2001;12(2-3):207-17. doi: 10.1016/s1359-6101(00)00028-9.

Abstract

Human T-cell leukemia virus type I (HTLV-I) is the etiological agent for adult T-cell leukemia (ATL), as well as for tropical spastic paraparesis (TSP) and HTLV-I associate myelopathy (HAM). A biological understanding of the involvement of HTLV-I and in ATL has focused significantly on the workings of the virally-encoded 40 kDa phospho-oncoprotein, Tax. Tax is a transcriptional activator. Its ability to modulate the expression and function of many cellular genes has been reasoned to be a major contributory mechanism explaining HTLV-I-mediated transformation of cells. In activating cellular gene expression, Tax impinges upon several cellular signal-transduction pathways, including those for CREB/ATF and NF-kappa B. In this paper, we review aspects of Tax's transcriptional potential with particular focus on recent evidence linking Tax to IKK (I kappa B-kinase)-complex and MAP3Ks (mitogen-activated protein kinase kinase kinases).

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Nucleus / metabolism
  • Cell Transformation, Neoplastic / metabolism
  • Cytoplasm / metabolism
  • Gene Expression Regulation*
  • Gene Products, tax / chemistry
  • Gene Products, tax / metabolism*
  • Human T-lymphotropic virus 1 / metabolism*
  • Humans
  • I-kappa B Kinase
  • Leukemia-Lymphoma, Adult T-Cell / metabolism
  • Leukemia-Lymphoma, Adult T-Cell / pathology
  • Leukemia-Lymphoma, Adult T-Cell / virology
  • MAP Kinase Kinase Kinases / metabolism
  • NF-kappa B / metabolism*
  • Protein-Serine-Threonine Kinases / metabolism
  • Signal Transduction*
  • Transcription Factors / metabolism

Substances

  • Gene Products, tax
  • NF-kappa B
  • Transcription Factors
  • Protein-Serine-Threonine Kinases
  • CHUK protein, human
  • I-kappa B Kinase
  • IKBKB protein, human
  • IKBKE protein, human
  • MAP Kinase Kinase Kinases