Functional activities of the human T-cell leukemia virus type I Tax oncoprotein: cellular signaling through NF-kappa B

K T Jeang

doi:10.1016/s1359-6101(00)00028-9

Functional activities of the human T-cell leukemia virus type I Tax oncoprotein: cellular signaling through NF-kappa B

Cytokine Growth Factor Rev. Jun-Sep 2001;12(2-3):207-17. doi: 10.1016/s1359-6101(00)00028-9.

Author

K T Jeang¹

Affiliation

¹ Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Room 306, Building 4, 4 Center Drive, MSC 0460, Bethesda, MD 20892-0460, USA. kj7e@nih.gov

PMID: 11325603
DOI: 10.1016/s1359-6101(00)00028-9

Abstract

Human T-cell leukemia virus type I (HTLV-I) is the etiological agent for adult T-cell leukemia (ATL), as well as for tropical spastic paraparesis (TSP) and HTLV-I associate myelopathy (HAM). A biological understanding of the involvement of HTLV-I and in ATL has focused significantly on the workings of the virally-encoded 40 kDa phospho-oncoprotein, Tax. Tax is a transcriptional activator. Its ability to modulate the expression and function of many cellular genes has been reasoned to be a major contributory mechanism explaining HTLV-I-mediated transformation of cells. In activating cellular gene expression, Tax impinges upon several cellular signal-transduction pathways, including those for CREB/ATF and NF-kappa B. In this paper, we review aspects of Tax's transcriptional potential with particular focus on recent evidence linking Tax to IKK (I kappa B-kinase)-complex and MAP3Ks (mitogen-activated protein kinase kinase kinases).

Publication types

Review

MeSH terms

Animals
Cell Nucleus / metabolism
Cell Transformation, Neoplastic / metabolism
Cytoplasm / metabolism
Gene Expression Regulation*
Gene Products, tax / chemistry
Gene Products, tax / metabolism*
Human T-lymphotropic virus 1 / metabolism*
Humans
I-kappa B Kinase
Leukemia-Lymphoma, Adult T-Cell / metabolism
Leukemia-Lymphoma, Adult T-Cell / pathology
Leukemia-Lymphoma, Adult T-Cell / virology
MAP Kinase Kinase Kinases / metabolism
NF-kappa B / metabolism*
Protein-Serine-Threonine Kinases / metabolism
Signal Transduction*
Transcription Factors / metabolism

Substances

Gene Products, tax
NF-kappa B
Transcription Factors
Protein-Serine-Threonine Kinases
CHUK protein, human
I-kappa B Kinase
IKBKB protein, human
IKBKE protein, human
MAP Kinase Kinase Kinases