Scleroderma in association with the use of docetaxel (taxotere) for breast cancer

Clin Exp Rheumatol. Mar-Apr 2001;19(2):197-200.


The taxanes, paclitaxel (Taxol) and docetaxal (Taxotere), are a new class of anti-microtubule agents which have shown cytotoxic activity in a number of solid tumours. Phase I and II trials confirm that docetaxal is highly active in the treatment of metastatic breast cancer. Reported toxicities of docetaxel include, dose limiting neutropenia, alopecia, skin reactions and fluid retention. Here we report the first case of rapid onset, diffuse scleroderma-like illness, which occurred in a 59-year-old female receiving treatment with docetaxel for locally invasive and advanced metastatic breast cancer.

Publication types

  • Case Reports

MeSH terms

  • Antineoplastic Agents, Phytogenic / adverse effects*
  • Breast Neoplasms / drug therapy*
  • Docetaxel
  • Female
  • Humans
  • Middle Aged
  • Paclitaxel / adverse effects*
  • Paclitaxel / analogs & derivatives
  • Scleroderma, Localized / chemically induced*
  • Taxoids*


  • Antineoplastic Agents, Phytogenic
  • Taxoids
  • Docetaxel
  • Paclitaxel