A statistical view of FMRFamide neuropeptide diversity

Mol Neurobiol. 2000 Feb-Apr;21(1-2):35-56. doi: 10.1385/MN:21:1-2:035.


FMRFamide-like peptide (FLP) amino acid sequences have been collected and statistically analyzed. FLP amino acid composition as a function of position in the peptide is graphically presented for several major phyla. Results of total amino acid composition and frequencies of pairs of FLP amino acids have been computed and compared with corresponding values from the entire GenBank protein sequence database. The data for pairwise distributions of amino acids should help in future structure-function studies of FLPs. To aid in future peptide discovery, a computer program and search protocol was developed to identify FLPs from the GenBank protein database without the use of keywords.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Database Management Systems*
  • FMRFamide / chemistry*
  • Humans
  • Molecular Sequence Data
  • Neuropeptides / chemistry
  • Sequence Analysis, Protein / methods*
  • Sequence Analysis, Protein / statistics & numerical data*


  • Neuropeptides
  • FMRFamide

Associated data

  • GENBANK/AB015417
  • GENBANK/AB019526
  • GENBANK/AF042387
  • GENBANK/AF042397
  • GENBANK/AF042399
  • GENBANK/AF047683
  • GENBANK/AF117896
  • GENBANK/M13649
  • GENBANK/M98854