In a randomized study, we included 23 osteoporotic patients with a distal radial fracture and loss of reduction after 1 week. The facture was re-reduced. In one group, a self-setting hydroxyapatite, Norian SRS, was injected into the fracture and the wrist was immobilized for 2 weeks with a dorsal splint (n 12). In the other group, the fracture was immobilized for 5 weeks with an external fixator (n 11). During the operation, the fracture fragments were marked with tantalum markers, so that loss of reduction during the immobilization and after mobilization could be studied with radiostereometric analysis (RSA). We found some recurrence of compression in the fracture in both groups during immobilization. After mobilization, the motion of the fracture, measured by displacement of the fragments along the longitudinal axis, was less than 2 mm, except in 3 cases treated with Norian SRS. A compression along the longitudinal axis of less than 2 mm is not likely to cause any problem in the long term. From the first to the last investigation, 7/12 patients with Norian SRS and 4/11 with external fixation lost more than 2 mm of the reduction along the longitudinal axis. We conclude that 5 weeks of immobilization is sufficient for healing with external fixation in this age group. This immobilization time might be reduced to 2 weeks for fractures treated with Norian SRS, but additional hardware should be used to ensure stability of the fracture system.