Activity of amphotericin B in lipid emulsion in the initial treatment of canine leishmaniasis

J Small Anim Pract. 2001 Apr;42(4):170-5. doi: 10.1111/j.1748-5827.2001.tb01797.x.

Abstract

Amphotericin B was given to 19 dogs with leishmaniasis. The drug was diluted in an emulsion prepared by mixing 50 mg of amphotericin B desoxycholate with 40 ml of sterile water and 10 ml of soya bean oil solution. The dogs were infused over nearly one hour with 50 ml/kg of normal saline followed by 10 ml/kg of mannitol 20 per cent. The mixture was then loaded over 30 to 60 minutes using a syringe pump. The emulsion was given twice weekly, at an increasing dosage (from 1 to 2.5 mg/kg bodyweight), for a minimum of eight injections. All 17 dogs receiving a total dosage of more than 10 mg/kg were clinically cured by the end of the treatment, and 14 of these had a negative polymerase chain reaction test on bone marrow.

MeSH terms

  • Amphotericin B / administration & dosage*
  • Amphotericin B / adverse effects
  • Animals
  • Antiprotozoal Agents / administration & dosage*
  • Antiprotozoal Agents / adverse effects
  • Dog Diseases / drug therapy*
  • Dogs
  • Drug Administration Schedule
  • Fat Emulsions, Intravenous / administration & dosage
  • Female
  • Humans
  • Infusions, Intravenous / veterinary
  • Leishmania infantum*
  • Leishmaniasis / drug therapy
  • Leishmaniasis / veterinary*
  • Male
  • Treatment Outcome
  • Zoonoses

Substances

  • Antiprotozoal Agents
  • Fat Emulsions, Intravenous
  • Amphotericin B