Cloning, mapping, genomic organization, and expression of mouse M-LP, a new member of the peroxisomal membrane protein Mpv17 domain family

Biochem Biophys Res Commun. 2001 May 4;283(2):292-6. doi: 10.1006/bbrc.2001.4769.


We have identified a mouse full-length cDNA and gene encoding a novel protein (M-LP), based on an expressed sequence tag (EST) sequence (GenBank Accession No. AI482564) obtained by differential display screening of age-dependently expressed genes in mouse kidney. The ML-P gene is composed of three exons, ranges over 5 kb on mouse chromosome 16B1-B2 and is expressed as two transcripts (1455 and 3058 bp), both of which include the same open-reading frame encoding 194 amino acids. M-LP is expressed mainly in kidney and spleen and shows age-dependent expression. M-LP has sequence homologies and membrane topologies very similar to the Mpv17 protein, a peroxisomal protein involved in the development of early-onset glomerulosclerosis. Search of the protein domain family database (ProDom) revealed that M-LP is a new member of the Mpv17 domain family (PD008400).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Chromosome Mapping
  • Cloning, Molecular
  • DNA Primers / genetics
  • DNA, Complementary / genetics
  • Exons
  • Gene Expression
  • Genome
  • In Situ Hybridization, Fluorescence
  • Introns
  • Kidney / metabolism
  • Membrane Proteins / chemistry
  • Membrane Proteins / genetics*
  • Mice
  • Mice, Inbred C57BL
  • Molecular Sequence Data
  • Peroxisomes / genetics
  • Protein Structure, Tertiary
  • Proteins / chemistry
  • Proteins / genetics*
  • Sequence Homology, Amino Acid


  • DNA Primers
  • DNA, Complementary
  • Membrane Proteins
  • Mpv17 protein, mouse
  • Mpv17l protein, mouse
  • Proteins

Associated data

  • GENBANK/AI482564