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Comparative Study
. 2001 May 4;283(2):417-22.
doi: 10.1006/bbrc.2001.4774.

Isolation of a Family of Organic Anion Transporters From Human Liver and Kidney

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Comparative Study

Isolation of a Family of Organic Anion Transporters From Human Liver and Kidney

W Sun et al. Biochem Biophys Res Commun. .

Abstract

Five distinct organic anion transporter cDNAs, hOAT1-5, were isolated from human liver and kidney. hOAT1, 2, and 3 are homologous to their respective rat orthologues OAT1-3, whereas hOAT4 and 5 are novel clones that have not been identified in other species. hOAT1- and hOAT3-transfected cells showed uptake of p-aminohippurate and fluorescein. Cells expressing hOAT2 showed uptake of p-aminohippurate, methotrexate, cAMP, and alpha-ketoglutarate. Northern blot analysis indicated differential tissue distribution for the transporter transcripts. These results indicate the existence of a family of organic anion transporting proteins in humans distinct from the oatp-like family of transporters.

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