Colonic intra-epithelial carcinoma occurring in a hyperplastic polyp via a serrated adenoma

Pathol Int. 2001 Mar;51(3):215-20. doi: 10.1046/j.1440-1827.2001.01177.x.


We present a case of intra-epithelial carcinoma occurring in a serrated adenoma of the colon. The pedunculated polyp, which measured 12 x 10 x 6 mm, was endoscopically removed from the ascending colon of a 78-year-old woman. Histologically, the polyp mainly consisted of serrated adenomatous glands, and had foci of intra-epithelial carcinoma at the top. Hyperplastic (metaplastic) areas were also present in both borders between the serrated adenomatous area and the surrounding normal mucosa. A sequential increase in the degree of dysplasia, and in the number of nuclei positively reactive for Ki-67 and p53 was evident from the hyperplastic areas toward the foci of carcinoma. The polyp described here may represent a carcinogenic potential of hyperplastic polyp via serrated adenoma.

Publication types

  • Case Reports

MeSH terms

  • Adenocarcinoma / metabolism
  • Adenocarcinoma / pathology*
  • Adenoma / metabolism
  • Adenoma / pathology*
  • Aged
  • Colonic Polyps / metabolism
  • Colonic Polyps / pathology*
  • Colorectal Neoplasms / metabolism
  • Colorectal Neoplasms / pathology*
  • Female
  • Humans
  • Immunohistochemistry
  • Ki-67 Antigen / metabolism
  • Neoplasms, Multiple Primary
  • Tumor Suppressor Protein p53 / metabolism


  • Ki-67 Antigen
  • Tumor Suppressor Protein p53