Suppressive effect of Lactobacillus gasseri OLL 2716 (LG21) on Helicobacter pylori infection in humans

J Antimicrob Chemother. 2001 May;47(5):709-10. doi: 10.1093/jac/47.5.709.


To examine the efficacy of Lactobacillus gasseri OLL2716 (LG21) as a probiotic for Helicobacter pylori in humans, 31 subjects infected with the bacterium ingested yogurt containing LG21 daily for an 8 week period. The [(13)C]urea breath test and assays of serum pepsinogens revealed a significant improvement following LG21 treatment. LG21 was thus determined to be effective in both suppressing H. pylori and reducing gastric mucosal inflammation.

Publication types

  • Clinical Trial

MeSH terms

  • Female
  • Helicobacter Infections / blood
  • Helicobacter Infections / therapy*
  • Helicobacter pylori / physiology*
  • Humans
  • Lactobacillus / physiology*
  • Male
  • Middle Aged
  • Pepsinogen A / blood
  • Pepsinogen C / blood
  • Probiotics / therapeutic use*
  • Treatment Outcome


  • Pepsinogen C
  • Pepsinogen A