The cellular neurobiology of depression

Nat Med. 2001 May;7(5):541-7. doi: 10.1038/87865.


Major depressive disorders, long considered to be of neurochemical origin, have recently been associated with impairments in signaling pathways that regulate neuroplasticity and cell survival. Agents designed to directly target molecules in these pathways may hold promise as new therapeutics for depression.

Publication types

  • Review

MeSH terms

  • Antidepressive Agents / pharmacology
  • Antidepressive Agents / therapeutic use
  • Cell Survival / drug effects
  • Depressive Disorder / drug therapy
  • Depressive Disorder / metabolism
  • Depressive Disorder / pathology*
  • Glucocorticoids / pharmacology
  • Neuronal Plasticity / drug effects
  • Signal Transduction


  • Antidepressive Agents
  • Glucocorticoids