Relationship between bone marrow cellularity and apparent diffusion coefficient

J Magn Reson Imaging. 2001 May;13(5):757-60. doi: 10.1002/jmri.1105.


This study was performed to determine if there is a relationship between apparent diffusion coefficient (ADC) and cellularity of bone marrow of the posterior ilium. Four groups of various marrow cellularity underwent diffusion-weighted echo-planar imaging: 1) adults with normal hypocellularity (21 patients); 2) adults with normal normocellularity (13 patients); 3) young children with normal hypercellularity (5 patients); and 4) adults with lymphoma-related hypercellularity (3 patients). In all adults, marrow cellularity was confirmed by uni-or bilateral bone marrow biopsies. In children, the iliac marrow was presumed hypercellular because of their ages. A total of 66 ADC values of bone marrow calculated from diffusion-weighted images with b-values of 30 and 300 seconds/mm(2) was evaluated. Hypercellular marrow (normal and lymphoma-related) showed the highest mean ADC, and hypocellular the lowest ADC. Statistically significant differences were found between three groups of normal marrow: hypocellular, normocellular, and hypercellular. There is a positive correlation between ADC and cellularity of bone marrow. J. Magn. Reson. Imaging 2001;13:757-760.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Biopsy, Needle
  • Bone Marrow / pathology*
  • Bone Marrow Neoplasms / pathology*
  • Child, Preschool
  • Diffusion
  • Echo-Planar Imaging*
  • Female
  • Humans
  • Image Enhancement*
  • Infant
  • Lymphoma / pathology*
  • Magnetic Resonance Imaging*
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Reference Values