Fast (13)C-glucose metabolite mapping in rat brain using (1)H echo planar spectroscopic imaging technique at 2T

S Morikawa; T Inubushi

doi:10.1002/jmri.1109

Fast (13)C-glucose metabolite mapping in rat brain using (1)H echo planar spectroscopic imaging technique at 2T

J Magn Reson Imaging. 2001 May;13(5):787-91. doi: 10.1002/jmri.1109.

Authors

S Morikawa¹, T Inubushi

Affiliation

¹ Molecular Neuroscience Research Center, Shiga University of Medical Science, Seta, Ohtsu, Shiga 520-2192, Japan. morikawa@belle.shiga-med.ac.jp

PMID: 11329202
DOI: 10.1002/jmri.1109

Abstract

For fast (13)C metabolite mapping in rat brains, (1)H-detected (13)C NMR spectroscopy using gradient-enhanced heteronuclear multiple-quantum coherence and (1)H echo planar spectroscopic imaging were combined. (13)C glucose and 3-/4-(13)C-Glu/Gln images of rat brain were successfully constructed with 35-minute temporal resolution under a 2T magnetic field. In the ischemic region of the suture middle cerebral artery occlusion model, glucose and Glu/Gln signals decreased and lactate signals appeared. J. Magn. Reson. Imaging 2001;13:787-791.

MeSH terms

Animals
Blood Glucose / metabolism*
Brain / pathology
Brain / physiopathology
Brain Ischemia / diagnosis
Brain Ischemia / physiopathology*
Brain Mapping*
Echo-Planar Imaging*
Energy Metabolism / physiology*
Glutamine / metabolism
Image Enhancement*
Image Processing, Computer-Assisted*
Magnetic Resonance Spectroscopy*
Male
Predictive Value of Tests
Rats
Rats, Sprague-Dawley

Substances

Blood Glucose
Glutamine