Peroxisomal beta-oxidation enzymes

Cell Biochem Biophys. 2000:32 Spring:63-72. doi: 10.1385/cbb:32:1-3:63.


Peroxisomal fatty acid oxidation enzymes are summarized in comparison to their mitochondrial counterparts. The peroxisomal enzymes involved in the beta-oxidation spiral are schematically classified into two groups. The first group consists of hitherto purified and characterized classical enzymes: palmitoyl-CoA oxidase, the L-bifunctional protein, and 3-ketoacyl-CoA. These enzymes are inducible and act on the straight chain substrates. The second group consists of recently identified enzymes, branched-chain oxidase, the D-bifunctional protein, and sterol-carrier protein x, which catalyze four reactions of beta-oxidation cycle. These are noninducible and act on branched-chain substrates.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Fatty Acids / metabolism*
  • Humans
  • Oxidation-Reduction
  • Oxidoreductases / metabolism*
  • Peroxisomes / metabolism*
  • Substrate Specificity


  • Fatty Acids
  • Oxidoreductases