Abstract
Tumor necrosis factor (TNF)-alpha-induced hepatitis and apoptosis, as respectively assessed by serum enzyme activities and hepatic DNA fragmentation were effectively suppressed by a single force-feeding of caffeine (100 mg/kg) 1.5 h before injecting the drug. In contrast, caffeine had no significant effect on anti-Fas antibody-induced hepatitis and apoptosis. These results suggest that caffeine differentially affected TNF-alpha receptor- and Fas-mediated hepatitis and apoptosis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alanine Transaminase / blood
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Animals
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Antibodies, Monoclonal / immunology
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Apoptosis / immunology*
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Aspartate Aminotransferases / blood
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Caffeine / administration & dosage
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Caffeine / immunology*
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Chemical and Drug Induced Liver Injury / immunology*
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DNA Fragmentation
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Disease Models, Animal
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Lipopolysaccharides / adverse effects
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Mice
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Tumor Necrosis Factor-alpha / adverse effects*
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Tumor Necrosis Factor-alpha / immunology
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fas Receptor / immunology*
Substances
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Antibodies, Monoclonal
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Lipopolysaccharides
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Tumor Necrosis Factor-alpha
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fas Receptor
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Caffeine
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Aspartate Aminotransferases
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Alanine Transaminase