Suppressive effect of caffeine on hepatitis and apoptosis induced by tumor necrosis factor-alpha, but not by the anti-Fas antibody, in mice

Biosci Biotechnol Biochem. 2001 Mar;65(3):674-7. doi: 10.1271/bbb.65.674.

Abstract

Tumor necrosis factor (TNF)-alpha-induced hepatitis and apoptosis, as respectively assessed by serum enzyme activities and hepatic DNA fragmentation were effectively suppressed by a single force-feeding of caffeine (100 mg/kg) 1.5 h before injecting the drug. In contrast, caffeine had no significant effect on anti-Fas antibody-induced hepatitis and apoptosis. These results suggest that caffeine differentially affected TNF-alpha receptor- and Fas-mediated hepatitis and apoptosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alanine Transaminase / blood
  • Animals
  • Antibodies, Monoclonal / immunology
  • Apoptosis / immunology*
  • Aspartate Aminotransferases / blood
  • Caffeine / administration & dosage
  • Caffeine / immunology*
  • Chemical and Drug Induced Liver Injury / immunology*
  • DNA Fragmentation
  • Disease Models, Animal
  • Lipopolysaccharides / adverse effects
  • Mice
  • Tumor Necrosis Factor-alpha / adverse effects*
  • Tumor Necrosis Factor-alpha / immunology
  • fas Receptor / immunology*

Substances

  • Antibodies, Monoclonal
  • Lipopolysaccharides
  • Tumor Necrosis Factor-alpha
  • fas Receptor
  • Caffeine
  • Aspartate Aminotransferases
  • Alanine Transaminase