Tolerance during sedation in a pediatric ICU patient: effects on the BIS monitor

J Clin Anesth. 2001 Mar;13(2):122-4. doi: 10.1016/s0952-8180(00)00232-4.

Abstract

The authors demonstrate the effects of tolerance as measured using the bispectral index (BIS) monitor. Over a 5-day period, there was a twofold increase in the dose of midazolam and a threefold increase in the dose of fentanyl required to provide the same level of sedation and the same BIS number in a 9 year old boy receiving sedation during mechanical ventilation.

Publication types

  • Case Reports

MeSH terms

  • Adjuvants, Anesthesia*
  • Anesthesia*
  • Anesthetics*
  • Anesthetics, Intravenous*
  • Child
  • Down Syndrome / complications
  • Drug Tolerance
  • Electroencephalography / drug effects*
  • Fentanyl*
  • Humans
  • Hypnotics and Sedatives*
  • Intensive Care Units, Pediatric
  • Male
  • Midazolam*
  • Monitoring, Physiologic
  • Respiration, Artificial
  • Respiratory Insufficiency / therapy
  • Shock, Septic / therapy

Substances

  • Adjuvants, Anesthesia
  • Anesthetics
  • Anesthetics, Intravenous
  • Hypnotics and Sedatives
  • Midazolam
  • Fentanyl