Abstract
The authors demonstrate the effects of tolerance as measured using the bispectral index (BIS) monitor. Over a 5-day period, there was a twofold increase in the dose of midazolam and a threefold increase in the dose of fentanyl required to provide the same level of sedation and the same BIS number in a 9 year old boy receiving sedation during mechanical ventilation.
MeSH terms
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Adjuvants, Anesthesia*
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Anesthesia*
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Anesthetics*
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Anesthetics, Intravenous*
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Child
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Down Syndrome / complications
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Drug Tolerance
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Electroencephalography / drug effects*
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Fentanyl*
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Humans
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Hypnotics and Sedatives*
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Intensive Care Units, Pediatric
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Male
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Midazolam*
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Monitoring, Physiologic
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Respiration, Artificial
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Respiratory Insufficiency / therapy
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Shock, Septic / therapy
Substances
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Adjuvants, Anesthesia
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Anesthetics
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Anesthetics, Intravenous
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Hypnotics and Sedatives
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Midazolam
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Fentanyl