Anesthetic management of toxic epidermal necrolysis: report of three adult cases

J Clin Anesth. 2001 Mar;13(2):133-7. doi: 10.1016/s0952-8180(01)00238-0.


Toxic epidermal necrolysis is a rare but acute life-threatening syndrome in which the epidermis blisters and peels in large sheets. In general, patients with this syndrome are managed as severe second-degree burn patients, but special consideration should be given to mucous membrane involvement that reduces fluid intake and worsens the fluid deficit, systemic involvement that makes these patients hemodynamically unstable, and progression of cutaneous lesions that enhances the risk of infection and sepsis.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anesthesia*
  • Anti-Infective Agents / adverse effects
  • Anticonvulsants / adverse effects
  • Female
  • Humans
  • Male
  • Phenytoin / adverse effects
  • Stevens-Johnson Syndrome / complications
  • Stevens-Johnson Syndrome / therapy*
  • Sulfonamides / adverse effects
  • Virus Diseases / complications


  • Anti-Infective Agents
  • Anticonvulsants
  • Sulfonamides
  • Phenytoin