Effectof sex, oral contraceptives, and glucose loading on apomorphine-induced growth hormone secretion

J Clin Endocrinol Metab. 1975 Jun;40(6):1094-8. doi: 10.1210/jcem-40-6-1094.

Abstract

Apomorphine-induced growth hormone (GH) secretion less in women either on or off oral contraceptives than in men. Women on oral contraceptives have a significantly greater peak GH response to apomorphine than women on no medication. The reason for these differences is unclear. Prior glucose loading in men significantly decreases the GH response to apomorphine. This suggests that stimulation of glucoreceptors antagonises dopaminergic modulation of GH secretion.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • Apomorphine / pharmacology*
  • Blood Glucose / metabolism
  • Contraceptives, Oral / pharmacology*
  • Female
  • Glucose / pharmacology*
  • Growth Hormone / blood*
  • Humans
  • Male
  • Menstruation
  • Middle Aged
  • Sex Factors
  • Time Factors

Substances

  • Blood Glucose
  • Contraceptives, Oral
  • Growth Hormone
  • Glucose
  • Apomorphine