Meiotic recombination hot spots and cold spots

Nat Rev Genet. 2001 May;2(5):360-9. doi: 10.1038/35072078.


Meiotic recombination events are distributed unevenly throughout eukaryotic genomes. This inhomogeneity leads to distortions of genetic maps that can hinder the ability of geneticists to identify genes by map-based techniques. Various lines of evidence, particularly from studies of yeast, indicate that the distribution of recombination events might reflect, at least in part, global features of chromosome structure, such as the distribution of modified nucleosomes.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Chromosome Mapping*
  • Crossing Over, Genetic
  • Histones / genetics
  • Humans
  • Meiosis / genetics*
  • Models, Genetic
  • Mutation
  • Prognosis
  • Recombination, Genetic*
  • Saccharomyces
  • Tandem Repeat Sequences / genetics


  • Histones