Back in the water: the return of the inositol phosphates

Nat Rev Mol Cell Biol. 2001 May;2(5):327-38. doi: 10.1038/35073015.


Following the discovery of inositol-1,4,5-trisphosphate as a second messenger, many other inositol phosphates were discovered in quick succession, with some understanding of their synthesis pathways and a few guesses at their possible functions. But then it all seemed to go comparatively quiet, with an explosion of interest in the inositol lipids. Now the water-soluble phase is once again becoming a focus of interest. Old and new data point to a new vista of inositol phosphates, with functions in many diverse aspects of cell biology, such as ion-channel physiology, membrane dynamics and nuclear signalling.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Eukaryotic Cells / metabolism*
  • Humans
  • Inositol Phosphates / metabolism*
  • Signal Transduction / physiology*
  • Water / metabolism*


  • Inositol Phosphates
  • Water