Rap1 signalling: adhering to new models

Nat Rev Mol Cell Biol. 2001 May;2(5):369-77. doi: 10.1038/35073073.


Ras-like GTPases are ubiquitously expressed, evolutionarily conserved molecular switches that couple extracellular signals to various cellular responses. Rap1, the closest relative of Ras, has attracted much attention because of the possibility that it regulates Ras-mediated signalling. Rap1 is activated by extracellular signals through several regulatory proteins, and it might function in diverse processes, ranging from modulation of growth and differentiation to secretion, integrin-mediated cell adhesion and morphogenesis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Humans
  • Molecular Sequence Data
  • Signal Transduction / physiology*
  • rap1 GTP-Binding Proteins / chemistry
  • rap1 GTP-Binding Proteins / physiology*


  • rap1 GTP-Binding Proteins