Distribution of mitochondrial DNA lineages among Native American tribes of Northeastern North America

Hum Biol. 2001 Feb;73(1):17-55. doi: 10.1353/hub.2001.0008.


The mtDNA haplogroups of 185 individuals from Native American tribes in Northeast North America were determined. A subset of these individuals was analyzed by sequencing hypervariable segments I and II of the control region. The haplogroup frequency distributions of populations in the Northeast exhibit regional continuity that predates European contact. A large amount of gene flow has occurred between Siouan-and Algonquian-speaking groups, probably due to an Algonquian intrusion into the Northeast. The data also support both the Macro-Siouan hypothesis and a relatively recent intrusion of Northern Iroquoians into the Northeast. These conclusions are consistent with archaeological and linguistic evidence.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Canada
  • DNA, Mitochondrial / genetics*
  • Gene Frequency
  • Genetic Variation
  • Genetics, Population*
  • Haplotypes / genetics*
  • Humans
  • Indians, North American / genetics*
  • New England
  • Polymorphism, Restriction Fragment Length


  • DNA, Mitochondrial