Feline immunodeficiency virus cell entry

J Virol. 2001 Jun;75(11):5433-40. doi: 10.1128/JVI.75.11.5433-5440.2001.


The process of feline immunodeficiency virus (FIV) cell entry was examined using assays for virus replication intermediates. FIV subtype B was found to utilize the chemokine receptor CXCR4, but not CCR5, as a cellular receptor. Zidovudine blocked formation of late viral replication products most effectively, including circular DNA genome intermediates. Our findings extend the role of CXCR4 as a primary receptor for CD4-independent cell entry by FIV.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cell Line
  • Immunodeficiency Virus, Feline / drug effects
  • Immunodeficiency Virus, Feline / physiology*
  • Receptors, CXCR4 / physiology
  • Receptors, Virus / physiology
  • Reverse Transcriptase Inhibitors / pharmacology
  • Virus Replication / drug effects
  • Zidovudine / pharmacology


  • Receptors, CXCR4
  • Receptors, Virus
  • Reverse Transcriptase Inhibitors
  • Zidovudine